In 1957, Prof. L. van Bogaert founded the 'Belgian Study Group for Multiple Sclerosis' in the framework of the Belgian association for neurology. The aim of this study group was to stimulate scientific research and organise a consultation service for people with MS.
Dr. Ch. J. Ketelaer was put in charge of this consultancy agency. Quite quickly, he saw there was also a need to set up an admissions and treatment centre for people with MS. In collaboration with the study group from the Belgian League for Multiple Sclerosis, an application was submitted to the then Ministry of Public Health. This application received a positive response and so the first specialist hospital for the diagnosis, treatment and rehabilitation for people with MS and related demyelinating disorders was established in 1960. The hospital was given the official name 'Nationaal Schiftings – en Readaptatiecentrum voor Multiple Sclerose vzw' (National Screening and Readaptation Centre for Multiple Sclerosis). In 1996 the institution's official name changed to 'National Multiple Sclerosis Centre vzw', abbreviated to NMSC.
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There were 20 hospital beds to begin with, and this number was increased to 134 in the years that followed. In the mid 1980s, the NMSC started to focus more on outpatient rehabilitation of people with MS. Since March 1993, the NMSC has been able to care for 70 people with MS in its outpatient rehabilitation programmes via a RIZIV rehabilitation convention.
Because outpatient treatment and care have become more important over recent years, the number of hospital beds was reduced by 14 in February 2015. The outpatient care plans were extended by providing 3 extra rehabilitation places and adding a Transmural MS Team which provides, among other things, multidisciplinary screening and care programmes 'on site' in other general and university hospitals.