2020

• Feasibility of real-time internet-based teleconsultation in patients with multiple sclerosis: interventional pilot study.

D'Haeseleer M, Eelen P, Sadeghi N, D'Hooghe MB, Van Schependom J, Nagels G.

J Med Internet Res. 2020 May 20. doi: 10.2196/18178. Epub ahead of print. PMID: 32447274.

 

• Spatiotemporal and spectral dynamics of multi-item working memory as revealed by the n-back task using MEG

Costers L, Van Schependom J, Laton J, Baijot J, Sjøgård M, Wens V, De Tiège X,     Goldman S, D'Haeseleer M, D'hooghe MB, Woolrich M, Nagels G.

Hum Brain Mapp. 2020 Mar 17. doi: 10.1002/hbm.24955. [Epub ahead of print]

 

• Gut microbiome variation is associated to Multiple Sclerosis phenotypic subtypes

Reynders T*, Devolder L*, Valles-Colomer M, Van Remoortel A, Joossens M, De Keyser J, Nagels G, D'hooghe M*, Raes J* (* joint first and last authorship)

Ann Clin Transl Neurol. 2020 Mar 12. doi: 10.1002/acn3.51004. [Epub ahead of print]

 

2019

• Long-term safety and effectiveness of natalizumab treatment in clinical practice: 10 years of real-world data from the Tysabri Observational Program (TOP).

Butzkueven H, Kappos L, Wiendl H, Trojano M, Spelman T, Chang I, Kasliwal R, Jaitly S,     Campbell N, Ho PR, Licata S; Tysabri Observational Program (TOP) Investigators.

J Neurol Neurosurg Psychiatry. 2020 Mar 31. pii: jnnp-2019-322326. doi: 10.1136/jnnp-2019-            322326. [Epub ahead of print]

 

• Role of cerebral hypoperfusion in multiple sclerosis (ROCHIMS): study protocol for a proof-of-concept randomized controlled trial with bosentan.

Hostenbach S, Pauwels A, Michiels V, Raeymaekers H, Van Binst AM, Van Merhaeghen-Wieleman A, Van Schuerbeek P, De Keyser J, D'Haeseleer M.

Trials. 2019 Mar14;20(1):164. doi: 10.1186/s13063-019-3252-4. PMID: 30871594; PMCID: PMC6416892.

 

• Correlations of health status indicators with perceived neuropsychological impairment and cognitive processing speed in multiple sclerosis

D’hooghe MB*, De Cock A*, Benedict RHB, Van Remoortel A, Eelen P, D’haeseleer M, Peeters     E, De Keyser J, Nagels G. *joint first authorship

Mult Scler Relat Disord. 2019 Dec 20;39:101904. doi: 10.1016/j.msard.2019.101904. [Epub        ahead of print]

 

• Stronger correlations between neurophysiological and peripheral disease biomarkers predict better prognosis in two severe diseases

Gidron Y, De Couck M, Reynders T, Marechal R, Engelborghs S, D'hooghe M

J Clin Med. 2019 Dec 20;9(1). pii: E26. doi: 10.3390/jcm9010026.

 

• Relation between heart rate variability and disease course in multiple sclerosis

Reynders T, Gidron Y, De Ville J, Bjerke M, Weets I, Van Remoortel A, Devolder L, D'haeseleer            M, De Keyser J, Nagels G, D’hooghe M

J Clin Med. 2019 Dec 18;9(1). pii: E3. doi: 10.3390/jcm9010003.

 

• Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets in

Van Schependom J, Guldolf K, D'hooghe M, Nagels G, D'haeseleer M

Transl Neurodegener. 2019 Dec 9;8:37. doi: 10.1186/s40035-019-0178-4. eCollection 2019.         Review. Erratum in: Transl Neurodegener. 2020 Jan 3;9:3.  

        

• The Impact of Cognitive Dysfunction on Locomotor Rehabilitation Potential in Multiple Sclerosis.

Denissen S, De Cock A, Meurrens T, Vleugels L, Van Remoortel A, Gebara B, D'Haeseleer M, D'Hooghe MB, Van Schependom J, Nagels G.

J Cent Nerv Syst Dis. 2019 Nov 6;11:1179573519884041. doi: 10.1177/1179573519884041.  eCollection 2019

 

• Altered transient brain dynamics in multiple sclerosis: Treatment or pathology?  

Van Schependom J, Vidaurre D, Costers L, Sjogard M, D'Hooghe M, D'haeseleer M, Wens V, De Tiège X, Goldman S, Woolrich M, Nagels G Hum Brain Mapp 2019.

First published: 30 July 2019. https://doi.org/10.1002/hbm.24737

 

• Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk. 

International Multiple Sclerosis Genetics Consortium. Electronic address: chris.cotsapas@yale.edu;

International Multiple Sclerosis Genetics Consortium. Cell. 2019 Jun 27;178(1):262. doi: 10.1016/j.cell.2019.06.016. 
 

• Assessing life balance of European people with multiple sclerosis: a multicenter clinimetric study within the RIMS network
   
• The Impact of Cognitive Dysfunction on Locomotor Rehabilitation Potential in Multiple Sclerosis

Fluoxetine in Progressive Multiple Sclerosis : the FLUOX-PMS trial Cambron M, Mostert J, D'Hooghe M, Nagels G, Willekens B, Debruyne J, Algoed L, Verhagen W, Hupperts R, Heersema D, De Keyser J; FLUOX-PMS Study Group.

Mult Scler. 2019 Jun 20:1352458519843051. doi: 10.1177/1352458519843051
 

• Perceived Neuropsychological Impairment Inversely Related to Self-reported Health and Employment in Multiple Sclerosis. 

D'hooghe MB, De Cock A, Benedict RHB, Gielen J, Van Remoortel A, Eelen P, Van Merhaegen A, De Keyser J, D'haeseleer M, Peeters E, Nagels G Eur J Neurol. 2019 Jun 10. doi: 10.1111/ene.14012. [Epub ahead of print]
 

• Single MRI-based volumetric assessment in clinical practice is associated with MS-related disability 

D'hooghe MB, Gielen J, Van Remoortel A, D'haeseleer M, Peeters E, Cambron M, De Keyser J, Nagels G.  J Magn Reson Imaging. 2019 May;49(5):1312-1321. doi: 10.1002/jmri.26303. Epub 2018 Dec 31.
 

• Neuraxial analgesia is not associated with an increased risk of post-partum relapses in MS  

Lavie C, Rollot F, Durand-Dubief F, Marignier R, Ionescu I, Casey R, Moreau T, Tourniaire P, Hutchinson M, D’Hooghe MB, Laplaud D-A, Clavelou P, De Sèze J, Debouverie M, Brassat D, Pelletier J, Lebrun-Frenay C, Le Page E, Castelnovo G, Berger E, Hautecoeur P, Heinzlef O, Durelli L, Clerico M, Trojano M, Patti F and Vukusic S; for the PRIMS and POPARTMUS investigators Mult Scler. 2019 Apr;25(4):591-600. doi: 10.1177/1352458518763080. Epub 2018 Mar 20.
 

• Role of cerebral hypoperfusion in multiple sclerosis (ROCHIMS): study protocol for a proof-of-concept randomized controlled trial with bosentan. 

Hostenbach S, Pauwels A, Michiels V, Raeymaekers H, Van Binst AM, Van Merhaeghen-Wieleman A, Van Schuerbeek P, De Keyser J, D'Haeseleer M. Trials. 2019 Mar 14;20(1):164. doi: 10.1186/s13063-019-3252-4.
 

• Do the posterior midline cortices belong to the electrophysiological default-mode network? 

Sjøgård M, De Tiège X, Mary A, Peigneux P, Goldman S, Nagels G, van Schependom J, Quinn AJ, Woolrich MW, Wens V. Neuroimage. 2019 Jun 22;200:221-230. doi: 10.1016/j.neuroimage.2019.06.052. [Epub ahead of print]

2018

• Single MRI-Based Volumetric Assessment in Clinical Practice Is Associated With MS-Related Disability. D'hooghe MB, Gielen J, Van Remoortel A, D'haeseleer M, Peeters E, Cambron M, De Keyser J, Nagels G. J Magn Reson Imaging. 2018, doi: 10.1002/jmri.26303.
   
• Early-Onset Creutzfeldt-Jakob Disease Mimicking Immune-Mediated Encephalitis. Wiels WA, Du Four S, Seynaeve L, Flamez A, Tousseyn T, Thal D, D'Haeseleer M. Front Neurol. 2018;9:242. doi: 10.3389/fneur.2018.00242. eCollection 2018.
   
• Plasma citrulline levels are increased in patients with multiple sclerosis. Vande Vyver M, Beelen R, De Keyser J, Nagels G, Van Binst AM, Verborgh C, D'haeseleer M. J Neurol Sci. 2018;387:174-178. doi: 10.1016/j.jns.2018.02.025. Epub 2018 Feb 16.
   
• A Belgian consensus protocol for autologous hematopoietic stem cell transplantation in multiple sclerosis. Laureys G, Willekens B, Vanopdenbosch L, Deryck O, Selleslag D, D'Haeseleer M, De Becker A, Dubois B, Dierickx D, Perrotta G, De Wilde V, van Pesch V, Straetmans N, Dive D, Beguin Y, Van Wijmeersch B, Theunissen K, Kerre T, Van de Velde A. Acta Neurol Belg. 2018;118(2):161-168. doi: 10.1007/s13760-018-0905-0. Epub 2018 Mar 13.
   
• Thyroid disorders in alemtuzumab-treated multiple sclerosis patients: a Belgian consensus on diagnosis and management. Decallonne B, Bartholomé E, Delvaux V, D'haeseleer M, El Sankari S, Seeldrayers P, Van Wijmeersch B, Daumerie C. Acta Neurol Belg. 2018;118(2):153-159. doi: 10.1007/s13760-018-0883-2. Epub 2018 Jan 25.
   
• The effect of task modality and stimulus frequency in paced serial addition tests on functional brain activity. Gielen J, Wiels W, Van Schependom J, Laton J, Van Hecke W, Parizel PM, D'hooghe MB, Nagels G. PLoS One. 2018;13(3):e0194388. doi: 10.1371/journal.pone.0194388.
   
• Het ontrafelen van de rol van darmflore bij Multiple Sclerose. M. D'hooghe, J. Raes, J. De Keyser, A. Van Remoortel, L. Devolder, A. Pauwels. MS Link (2018). 4-5.  Lees het artikel hier
   
• Improving fatigue in multiple sclerosis by smartphone-supported energy management: The MS TeleCoach feasibility study. Marie D'hooghe, Geert Van Gassen, Daphne Kos, Olivier Bouquiaux, Melissa Cambron, Danny Decoo, Andreas Lysandropoulos, Bart Van Wijmeersch, Barbara Willekens, Iris-Katharina Penner, Guy Nagels. Multiple Sclerosis and Related Disorders 22 (2018) 90-96.
   
• Development of the Arm Function in Multiple Sclerosis Questionnaire-Short Form (AMSQ-SF): A static 10-item version Luijten MA, Eekhout I, D'Hooghe M, Uitdehaag BM, Mokkink LB. Mult Scler. 2018 Nov 9:1352458518808197. doi: 10.1177/1352458518808197.
   
• Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk. International Multiple Sclerosis Genetics Consortium.  Electronic address: chris.cotsapas@yale.edu; International Multiple Sclerosis Genetics Consortium. D'Hooghe M, Cell. 2018, pii: S0092-8674(18)31261-3. doi: 10.1016/j.cell.2018.09.049
  
   
• Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension. Kapoor R, Ho PR, Campbell N, Chang I, Deykin A, Forrestal F, Lucas N, Yu B, Arnold DL, Freedman MS, Goldman MD, Hartung HP, Havrdová EK, Jeffery D, Miller A, Sellebjerg F, Cadavid D, Mikol D, Steiner D; ASCEND investigators. Lancet Neurol. 2018, pii: S1474-4422(18)30069-3. doi: 10.1016/S1474-4422(18)30069
   

• Neuraxial analgesia is not associated with an increased risk of post-partum relapses in MS  Lavie C, Rollot F, Durand-Dubief F, Marignier R, Ionescu I, Casey R, Moreau T, Tourniaire P, Hutchinson M, D’Hooghe MB, Laplaud D-A, Clavelou P, De Sèze J, Debouverie M, Brassat D, Pelletier J, Lebrun-Frenay C, Le Page E, Castelnovo G, Berger E, Hautecoeur P, Heinzlef O, Durelli L, Clerico M, Trojano M, Patti F and Vukusic S; for the PRIMS and POPARTMUS investigators. Mult Scler. First Published March 2018.

2017

• Environmental modifiable risk factors for multiple sclerosis: Report from the 2016 ECTRIMS focused workshop. Maria Pia Amato, Tobias Derfuss, Bernard Hemmer, Roland Liblau, Xavier Montalban, Per Soelberg Sørensen and David H Miller; For the 2016 ECTRIMS Focused Workshop Group. Multiple Sclerosis Journal 1–14 DOI: 10.1177/1352458516686847
   
• Definition, prevalence and predictive factors of benign multiple sclerosis. Tatjana Reyndersa, Miguel D'haeseleer, Jacques De Keyser, Guy Nagels, Marie B. D'hooghe. eNeurologicalSci 7 (2017) 37–43

2016

• Reliability of measuring regional callosal atrophy in neurodegenerative diseases. Van Schependom J, Jain S, Cambron M, Vanbinst AM, De Mey J, Smeets D, Nagels G. Neuroimage Clin. 2016 Oct 15;12:825-831. PubMed PMID: 27830115; PubMed Central PMCID: PMC5094205.

• Self-reported levels of education and disability progression in multiple sclerosis. D'hooghe MB, Haentjens P, Van Remoortel A, De Keyser J, Nagels G. Acta Neurol Scand. 2016 Dec;134(6):414-419. doi: 10.1111/ane.12555. PubMed PMID: 27761897.

• Measurements of brain atrophy in individual patients with multiple sclerosis. Smeets D, Ribbens A, Sima DM, Cambron M, Horakova D, Jain S, Maertens A, Van Vlierberghe E, Terzopoulos V, Van Binst AM, Vaneckova M, Krasensky J, Uher T,Seidl Z, De Keyser J, Nagels G, De Mey J, Havrdova E, Van Hecke W. Reliable Brain Behav. 2016 Jul 19;6(9):e00518. PubMed PMID: 27688944; PubMed Central PMCID: PMC5036437.

• European Long-term Follow-up Study Group in Interferon β-1b in Secondary-progressive Multiple Sclerosis.. A 10-year follow-up of the European multicenter trial of interferon β-1b in secondary-progressive multiple sclerosis. Kuhle J, Hardmeier M, Disanto G, Gugleta K, Ecsedi M, Lienert C, Amato MP, Baum K, Buttmann M, Bayas A, Brassat D, Brochet B, Confavreux C, Edan G, Färkkilä M, Fredrikson S, Frontoni M, D'Hooghe M, Hutchinson M, De Keyser J, Kieseier BC, KÃmpfel T, Rio J, Polman C, Roullet E, Stolz C, Vass K, Wandinger KP, Kappos L; Mult Scler. 2016 Apr;22(4):533-43. doi: 10.1177/1352458515594440. PubMed PMID: 26362898.

• The effectiveness of a self-management occupational therapy intervention on activity performance in individuals with multiple sclerosis-related fatigue: a randomized-controlled trial.  Kos D, Duportail M, Meirte J, Meeus M, D'hooghe MB, Nagels G, Willekens B,Meurrens T, Ilsbroukx S, Nijs J. Int J Rehabil Res. 2016 Sep;39(3):255-62. doi: 10.1097/MRR.178. PubMed PMID:27182847.

• Feasibility, Reliability and Predictive Value Of In-Ambulance Heart Rate Variability Registration. Yperzeele L, van Hooff RJ, De Smedt A, Nagels G, Hubloue I, De Keyser J, Brouns R. PLoS One. 2016 May 4;11(5):e0154834. doi:10.1371/journal.pone.0154834. PubMed PMID: 27144492; PubMed Central PMCID: PMC4856404.

• Improved patient-reported health impact of multiple sclerosis: The ENABLE study of PR-fampridine. Macdonell R, Nagels G, Laplaud DA, Pozzilli C, de Jong B, Martins da Silva A,Nicholas R, Lechner-Scott J, Gaebler JA, Agarwal S, Wang P, Yeh M, Hovenden M,Soelberg Sørensen P. Mult Scler. 2016 Jun;22(7):944-54. doi: 10.1177/1352458515606809. PubMed PMID: 26447066.

• Assessing PML risk under immunotherapy: if all you have is a hammer, everything looks like a nail. Van Schependom J, Gielen J, Laton J, Nagels G. Mult Scler. 2016 Mar;22(3):389-92. doi: 10.1177/1352458515596458. PubMed PMID: 26199353.

• Self-Critical Perfectionism, Dependency, and Symptomatic Distress in Patients With Personality Disorder During Hospitalization-based Psychodynamic Treatment: A Parallel Process Growth Modeling Approach. Lowyck B, Luyten P, Vermote R, Verhaest Y, Vansteelandt K. Personal Disord. 2016 May 30. [Epub ahead of print] PubMed PMID: 27244268.

• What's in a face? Mentalizing in borderline personality disorder based on dynamically changing facial expressions. Lowyck B, Luyten P, Vanwalleghem D, Vermote R, Mayes LC, Crowley MJ. Personal Disord. 2016 Jan;7(1):72-9. doi: 10.1037/per0000144. PubMed PMID: 26461044.

• The Construct Validity of the Dutch Personality Inventory for DSM-5 Personality Disorders (PID-5) in a Clinical Sample. Assessment. Bastiaens T, Claes L, Smits D, De Clercq B, De Fruyt F, Rossi G, Vanwalleghem D, Vermote R, Lowyck B, Claes S, De Hert M. 2016 Feb;23(1):42-51. doi: 10.1177/1073191115575069. PubMed PMID: 25736039.

• The pathophysiological role of astrocytic endothelin-1. Hostenbach S, D'haeseleer M, Kooijman R, De Keyser J.Prog Neurobiol. 2016 Sep;144:88-102. doi: 10.1016/j.pneurobio.2016.04.009. Review. PMID:27132521

2015

• Status of diagnostic approaches to AQP4-IgG seronegative NMO and NMO/MS overlap syndromes. Juryńczyk M, Weinshenker B, Akman-Demir G, Asgari N, Barnes D, Boggild M, Chaudhuri A, D'hooghe MB, Evangelou N, Geraldes R, Illes Z, Jacob A, Kim HJ, Kleiter I, Levy M, Marignier R, McGuigan C, Murray K, Nakashima I, Pandit L, Paul F, Pittock S, Selmaj K, de Sèze J, Siva A, Tanasescu R, Vukusic S, Wingerchuk D, Wren D, Leite I, Palace J. J Neurol. 2016 Jan;263(1):140-9. doi: 10.1007/s00415-015-7952-8. Epub 2015 Nov 3.

• Do advanced statistical techniques really help in the diagnosis of the metabolic syndrome in patients treated with second-generation antipsychotics? Van Schependom J, Yu W, Gielen J, Laton J, De Keyser J, De Hert M, Nagels G. J Clin Psychiatry. 2015 Oct;76(10):e1292-9. doi: 10.4088/JCP.14m09367.

• Improved patient-reported health impact of multiple sclerosis: The ENABLE study of PR-fampridine.  Macdonell R, Nagels G, Laplaud DA, Pozzilli C, de Jong B, Martins da Silva A, Nicholas R,  Lechner-Scott J, Gaebler JA, Agarwal S, Wang P, Yeh M, Hovenden M, Soelberg Sørensen P. Mult Scler. 2015 Oct 7. pii: 1352458515606809.

• Risk Knowledge in Relapsing Multiple Sclerosis (RIKNO 1.0)--Development of an Outcome Instrument for Educational Interventions. Heesen C, Kasper J, Fischer K, Köpke S, Rahn A, Backhus I, Poettgen J, Vahter L, Drulovic J, Van Nunen A, Beckmann Y, Liethmann K, Giordano A, Fulcher G, Solari A; AutoMS-group. PLoS One. 2015 Oct 2;10(10):e0138364. doi: 10.1371/journal.pone.0138364. eCollection 2015.

• A 10-year follow-up of the European multicenter trial of interferon β-1b in secondary-progressive multiple sclerosis. Kuhle J, Hardmeier M, Disanto G, Gugleta K, Ecsedi M, Lienert C, Amato MP, Baum K, Buttmann M, Bayas A, Brassat D, Brochet B, Confavreux C, Edan G, Färkkilä M, Fredrikson S, Frontoni M, D'hooghe MB, Hutchinson M, De Keyser J, Kieseier BC, Kümpfel T, Rio J, Polman C, Roullet E, Stolz C, Vass K, Wandinger KP, Kappos L.; European Long-term Follow-up Study Group in Interferon β-1b in Secondary-progressive Multiple Sclerosis. Mult Scler. 2016 Apr;22(4):533-43. doi: 10.1177/1352458515594440. Epub 2015 Sep 11. PMID: 26362898

• Neurological patients and their lower limb orthotics: An observational pilot study about acceptance and satisfaction. Swinnen E, Lafosse C, Van Nieuwenhoven J, Ilsbroukx S, Beckwée D, Kerckhofs E. Prosthet Orthot Int. 2015 Aug 5. pii: 0309364615592696. PMID: 26246356
• Heart rate variability and baroreceptor sensitivity in acute stroke: a systematic review. Yperzeele L, van Hooff RJ, Nagels G, De Smedt A, De Keyser J, Brouns R. Int J Stroke. 2015 Aug;10(6):796-800. doi: 10.1111/ijs.12573. Review. PMID: 26202709
• Assessing PML risk under immunotherapy: if all you have is a hammer, everything looks like a nail. Van Schependom J, Gielen J, Laton J, Nagels G. Mult Scler. 2016 Mar;22(3):389-92. doi: 10.1177/1352458515596458. Epub 2015 Jul 21. PMID: 26199353

• Cerebral hypoperfusion: a new pathophysiologic concept in multiple sclerosis? D'Haeseleer M, Hostenbach S, Peeters I, Sankari SE, Nagels G, De Keyser J, D'hooghe MB. J Cereb Blood Flow Metab. 2015 Sep;35(9):1406-10. doi: 10.1038/jcbfm.2015.131. Epub 2015 Jun 24. Review.

• The Arm Function in Multiple Sclerosis Questionnaire (AMSQ): development and validation of a new tool using IRT methods. Mokkink LB, Knol DL, van der Linden FH, Sonder JM, D'hooghe MB, Uitdehaag BM. Disabil Rehabil. 2015 Jul 26:1-7.

• "How to conquer a mountain with multiple sclerosis". How a climbing expedition to Machu Picchu affects the way people with multiple sclerosis experience their body and identity: a phenomenological analysis. Calsius J, Courtois I, Feys P, Van Asch P, De Bie J, D'hooghe MB. Disabil Rehabil. 2015 Jul 2:1-7.

• The Construct Validity of the Dutch Personality Inventory for DSM-5 Personality Disorders (PID-5) in a Clinical Sample. Bastiaens T, Claes L, Smits D, De Clercq B, De Fruyt F, Rossi G, Vanwalleghem D, Vermote R, Lowyck B, Claes S, De Hert M. Assessment. 2016 Feb;23(1):42-51.

• Music therapy and depression. Van Assche E, De Backer J, Vermote R. Tijdschr Psychiatr. 2015;57(11):823-9. Dutch.

• What's in a face? Mentalizing in borderline personality disorder based on dynamically changing facial expressions. Lowyck B, Luyten P, Vanwalleghem D, Vermote R, Mayes LC, Crowley MJ. Personal Disord. 2016 Jan;7(1):72-9. doi: 10.1037/per0000144. Epub 2015 Oct 12.

• A psychoanalytically informed hospitalization-based treatment of personality disorders. Vermote R, Luyten P, Verhaest Y, Vandeneede B, Vertommen H, Lowyck B. Int J Psychoanal. 2015 Jun;96(3):817-43. doi: 10.1111/1745-8315.12394. PMID: 26173889